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Depression Definition
(also called unipolar depression or clinical depression) is a type of mental illness or mood disorder in which someone has strong sad feelings, feelings of guilt, helplessness, anxiety (worry), and/or fear, lowered self-esteem and a loss of interest in life which lasts for a long time. ...
Gene Abnormalities Implicated In Bipolar Disorder - Sodium, Calcium Imbalances Linked To Manic Depressive Episodes
The largest genetic analysis of its kind to date for bipolar disorder has implicated machinery involved in the balance of sodium and calcium in brain cells. Researchers supported in part by the National Institute of Mental Health, part of the National Institutes of Health, found an association between the disorder and variation in two genes that make components of channels that manage the flow of the elements into and out of cells, including neurons.
Astonishing 52 Percent Of Newly Diagnosed Bipolar Disorder Patients Receive Antidepressant Drugs In First-Line Treatment
Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that an astonishing 52.3 percent of newly diagnosed bipolar disorder patients are prescribed antidepressant drugs first line. The new report entitled Treatment Algorithms in Bipolar Disorder finds that this high preponderance of early-line antidepressant use stems from primary care physician prescribing.
FDA Approves First Generic Divalproex Sodium To Treat Seizures, Migraine Headaches And Bipolar Disorder
The U.S. Food and Drug Administration approved the first generic versions of Depakote delayed-release tablets (divalproex sodium). Depakote is approved by the FDA for the treatment of seizures, bipolar disorder and migraine headaches. "Generic drugs undergo a rigorous scientific review to ensure that they will provide the patient with the same amount of high quality, safe and effective drug as the name brand product," said Gary J.
Depression And Bipolar Results Worth Striving For - A New Recovery Model For Mental Illness
Bipolar Advantage Inc. will be introducing a new integrated recovery program called the "Advantage Program" on September 6, 2008. "The days of thinking a diagnosis of bipolar disorder means living a diminished life are over," says company president Tom Wootton.
Supplemental New Drug Application For Risperdal® Consta® Submitted To The FDA For The Treatment Of Bipolar Disorder
Alkermes, Inc. (NASDAQ: ALKS) today announced that its partner, Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD), submitted a supplemental New Drug Application (sNDA) for RISPERDAL® CONSTA® [(risperidone) Long-Acting Injection] to the U.S. Food and Drug Administration (FDA) for approval as monotherapy in the maintenance treatment of bipolar I disorder to delay the time to occurrence of mood episodes in adults.
Alexza Initiates Second Phase 3 Clinical Trial For AZ-004 (Staccato(R) Loxapine)
Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA) announced that it has initiated its second Phase 3 clinical trial with AZ-004 (Staccato(R) loxapine). AZ-004 is an inhalation product candidate being developed for the treatment of acute agitation in patients with schizophrenia or bipolar disorder.
Improving Traditional Psychiatric Diagnoses With Genetics
Psychiatry has begun the laborious effort of preparing the DSM-V, the new iteration of its diagnostic manual. In so doing, it once again wrestles with the task set by Carl Linnaeus, to "cleave nature at its joints." However, these "joints," the boundaries between psychiatric disorders, such as that between bipolar disorder and schizophrenia, are far from clear. Prior versions of DSM followed the path outlined by Emil Kraeplin in separating these disorders into distinct categories.
Partially Shared Genetic Profile Between Schizophrenia And Bipolar Disorder Discovered
Both schizophrenia and bipolar disorder can be disabling conditions, and both present clinically with significant mood and psychotic symptoms. These two illnesses also share genetic variants that might be involved in the predisposition to both disorders.
Astrazeneca Sponsors Service User- Involvement In Research Into Recovery For Mental Health
Two leading mental health charities, Rethink and MDF The BiPolar Organisation today announced the start of a new partnership with and project sponsored by AstraZeneca. It comprises of experiential research to identify what hinders and helps achieve recovery and aims to help to put recovery at the heart of mental health reform. It will report late 2008.
The ECNP Consensus Statement On Bipolar Depression
Bipolar disorder is one of the most complex and challenging mental disorder in the spectrum. Bipolar disorder is typically associated with considerable acute and longterm treatment needs and may be associated in the course of illness with times of tremendous social burden for both the individual and family. It is typically referred to as an episodic, yet lifelong and clinically severe mood disorder.
New Scholarship For Leaders Of Bipolar Lives
What do you do when you want to let the bipolar community know about scholarships for people with bipolar disorder, but soon discover that support for bipolar students is still far too rare? Why donate a scholarship yourself of course. The Bipolar Lives Scholarship is a new scholarship, created when journalist Sarah Freeman added a webpage on bipolar scholarships to the Bipolar Lives website, but found only a handful of suitable awards existed.
Mental Health Treatment: It's Commonly Accepted Yet Not So Easy To Obtain Or Understand
Seeing a psychologist or other mental health professional isn't an unusual thing; in fact it's relatively common. Nearly three in ten U.S. adults (29%) report that they have received treatment or therapy from a psychologist or other mental health professional. The survey also found that younger adults are more open to seeking mental health treatment than those over 50 and that many adults are not discouraged from seeking treatment because of stigma or fear of others finding out.
Relapse Time Prolonged In Clinically Stable Patients With Bipolar I Disorder Treated With Quetiapine As Adjunct Therapy To Mood Stabilisers
AstraZeneca announced the online publication of long-term SEROQUEL® (quetiapine fumarate) clinical trial data in the Journal of Affective Disorders. Results show that SEROQUEL in combination with lithium or divalproex significantly increased the time to recurrence of any mood event in patients with bipolar I disorder compared with lithium or divalproex alone.
FDA Approves First Generic Risperidone To Treat Psychiatric Conditions
The U.S. Food and Drug Administration approved the first generic versions of Risperdal (risperidone) tablets. Risperdal is an antipsychotic drug used for the treatment of schizophrenia, bipolar disorder, and other psychiatric conditions.
Link Between Poor Sleep And Suicidal Behavior Among Children And Adolescents With Depressive Episodes
A research abstract presented at SLEEP 2008, the 22nd Annual Meeting of the Associated Professional Sleep Societies (APSS), finds a link between poor sleep and suicidal behavior among children and adolescents with depressive episodes. The study, authored by Maria-Cecilia Lopes, MD, PhD, of Sao Paulo University in Brazil, focused on 303 individuals with pediatric bipolar disorder and pediatric unipolar disorder during depressive episodes.
Repligen Announces Plans To Initiate A Phase 2b Trial For RG2417 In Bipolar Disorder
Repligen Corporation (Nasdaq: RGEN) announced that based on feedback from the Food and Drug Administration, the Company plans to initiate a Phase 2b clinical trial of RG2417, an oral formulation of uridine, in patients with bipolar disorder later this year. This will be a multi-center, parallel arm placebo-controlled, clinical trial in which approximately 150 patients with bipolar disorder will receive either RG2417 or a placebo twice a day for eight-weeks.
Antidepressants Alone: Not For Bipolar Depression
Psychiatrists have cautioned against the use of antidepressants alone in people with bipolar disorders, saying they could worsen a patient's condition by causing a destabilisation in mood.
Report Confirms Increased Risk Of Smoking, Substance Abuse In Bipolar Adolescents
A study from the Massachusetts General Hospital (MGH) supports previous reports that adolescents with bipolar disorder are at increased risk for smoking and substance abuse. The article appearing in the June Drug and Alcohol Dependence - describing the largest such investigation to date and the first to include a control group - also indicates that bipolar-associated risk is independent of the risk conferred by other disorders affecting study participants.
NARSAD Researchers Identify Specific Genes And Family Traits Linked To Schizophrenia, Bipolar Disorder And Depression
New findings from research supported by NARSAD, the world's leading charity dedicated to mental health research, and conducted by Harvard-affiliated scientists are providing important clues into how genes work to impair various aspects of attention, memory and perception -- the behaviors associated with many psychiatric illnesses, such as schizophrenia, bipolar disorder and depression.
ABILIFY(R) (aripiprazole) Receives Expanded Indications For Maintenance Treatment In Pediatric Patients With Bipolar Disorder And Schizophrenia
Otsuka Pharmaceutical Co., Ltd. and Bristol-Myers Squibb Company (NYSE: BMY) announced that ABILIFY® (aripiprazole) received expanded indications in Bipolar I Disorder and Schizophrenia. ABILIFY is now indicated for maintenance treatment of manic and mixed episodes associated with Bipolar I Disorder with or without psychotic features in pediatric patients (aged 10-17) and maintenance treatment of Schizophrenia in adolescents (aged 13-17).
FDA Approves Astrazeneca's Seroquel For Maintenance Treatment In Bipolar Disorder
AstraZeneca announced that the U.S. Food and Drug Administration (FDA) has approved SEROQUEL® (quetiapine fumarate) for the maintenance treatment of patients with bipolar I disorder, as adjunct to lithium or divalproex. SEROQUEL is approved by the FDA for the treatment of schizophrenia, and is also the only single agent approved by the FDA for the treatment of both depressive episodes in bipolar disorder and acute manic episodes associated with bipolar I disorder1,2.
Perceptual Switch Rates With Ambiguous Structure-from-motion Figures In Bipolar Disorder
Most people believe that the way we see things is affected by how we feel emotionally. Does our mood really change what we see or do individuals with certain genetic traits always tend to see things differently, regardless of their mood? Earlier research suggested that people with bipolar mood disorder might alternate their perception more slowly when looking at ambiguous figures.
Overview Of Asenapine Data From Olympia Trial Program Presented At American Psychiatric Association Annual Meeting
Schering-Plough Corporation (NYSE: SGP) announced that an overview of asenapine clinical trials from the Olympia program was presented at the 161st Annual Meeting of the American Psychiatric Association in Washington, D.C., May 3-8. Data from the studies, involving patients with bipolar I disorder and schizophrenia, were presented in two oral presentations (Abstracts # 44 and # 80).
Problems Identified With Diagnosis Of Bipolar Disorder
A new study by Rhode Island Hospital and Brown University researchers reports that fewer than half the patients previously diagnosed with bipolar disorder received a diagnosis of bipolar disorder based on a comprehensive, psychiatric diagnostic interview - -the Structured Clinical Interview for DSM-IV (SCID).
Benefits Of Omega 3s Still Unclear For Bipolar Disorder
Despite intriguing findings that omega 3 fatty acid supplements could alleviate depression symptoms, there is still not enough evidence to say whether omega 3s are useful treatments for people with bipolar disorder, according to a review of recent studies.
 
 
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Depression can affect many things, such as mood, behavior and thought, because it is a psychological disorder. Because it can impede normal performance, often causes trouble with adjustment in work, family and society. You can end up feeling vulnerable and incapable of dealing with your thoughts, feelings and actions. Leaving untreated for years can result in lasting impairment. An overpowering feeling of sadness, accompanied by a loss of pleasure and feelings of worthlessness, is a symptom of depression.

People experience various symptoms and these may change over time. A person can have one or many of the symptoms during a depressed cycle. A non-disabling form of that consists of long-term, chronic symptoms is called dysthymia. While not curing depression, medication can make it easier to function and work out problems. Restoring the proper balance of neurotransmitters is the role of medication.

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With many types of depression, medication is used first to alleviate symptoms. A professional is able to assist you in getting whatever help you need. Essential to alleviating feelings of exhaustion and weakness is support from others. Some people find having a person to talk to helps. Family members who encourage and support can make all the difference.

Furthermore, schooling peers and gaining their support

Living with a Depressed Person
  It's time again to talk about an unpleasant subject. Unpleasant for me, and probably unpleasant for those of you who are depressed and have a spouse or lover or companion or partner who is not depressed. I was married for 46 years. My wife died only a few months ago. For many of those years, I had dysthymia, and thought that my problems were the most important in the world. I couldn't understand that I was causing some grief in the...
What I've Learned About Depression
Over the years, I've learned a few things about depression that would have surprised me when I first started having symptoms. More importantly, I've learned a few things about myself. If I'm angry at someone, but afraid to state my anger, I can get depressed. It used to take days or weeks before I figured out the cause. If someone's angry at me, I can get depressed. If I'm not depressed, but the stock market goes down, I get depressed. And it...
My Brother
When my brother killed himself eleven years ago, there was great consternation among his friends, his colleagues, and his family. How could such a skilled, well-known and respected journalist, with two Pulitzer Prizes, be so unhappy as to commit suicide?   My wife said, "I knew it would happen some day."   I asked her how she knew.   She said he had always been a deeply depressed person. He had no real support system beyond...
A Little Bit Hurts
The diagnosis at the bottom of my bill said, dysthymia.. My psychiatrist had told me that he was going to send that diagnosis to the insurance company. "What is it?" I asked. It was many, many years ago. I was in my 30s and re-starting therapy after moving across the country. My mood was not good. I felt inadequate to the task of finding work. I felt that people didn't like me. I felt that I wasn't going to succeed in life. All of this ran...
What I Do When I Get Depressed
Okay, this seems like a stupid question.   After all, there's nothing you can do when you get depressed, except take your meds, if you're on them; say your cognitive-behavioral mantras, if you're with that kind of a therapist; go to your therapist and cry.   Well, actually, there are other things I do to try to get straight.   Luckily, because I'm dysthymic (see last week's essay), not a severely depressed person, I...
Understanding Teen Depression
The other day my daughter asked me what I was going to write next. I told her that I had no idea, that I'd actually written everything I had to say about depression.   Horse-pucky, she said, using a wonderful family euphemism.  You have lots more to say about depression.   Okay, I asked, What?   Well, she said, What about all those years when you didn't know you were depressed. You didn't know the...
Depression or Sadness: How Do You Know?
Good day, folks.   I'm back from a year's absence, during which time I had chemotherapy for a resurgence of my on-going non-hodgkins lymphoma.   Just when I thought I was done with that, I had pneumonia; spent Thanksgiving of 2007 in the hospital. Very pleasant visits from my daughters and my wife.   Then, just when that was over, my wife suddenly died - no illness, no good reason, just a heart electrical malfunction. We...
Illness and Depression
 While I wait to hear how serious a threat my returned lymphoma is to my health, and what treatment I will receive, I tread two separate paths. The first is an upbeat, we’ll-weather-this-just-like-before path; the second is a road of I’m-depressed, I’m-depressed, I’m-depressed. I came home from the city yesterday absolutely exhausted at 4 p.m. My wife suggested a bath and a nap. I slept for two hours, had supper, then went back for...
Creativity and Depression
When I left my analyst’s office for the last time, way back in 1963, he told me one thing to keep me going. I was heading back to New York City, where I’d been born, after six years in California, learning my craft of film-making. “Keep doing creative things,” he said. I took that statement for granted. How else would I ply my trade if I didn’t do “creative things?” But the good doctor meant something much deeper. He meant...
The Dutch study on therapy
I read on this site that a Dutch study showed “that psychotherapy doesn’t work” with families in which there were suicides. To put it another way, people whose loved ones killed themselves have a hard time getting over their grief and psychotherapy didn’t seem to help. Marieke de Groot, at the University of Groningen, and team members explain that "complicated grief" has an unusually long duration of symptoms, which include avoiding...

can aid healing. Treatment of with medication and counseling often lessens or gets rid of symptoms. Some people find other treatment methods effective but not enough study has gone into those methods. How effective any one treatment is will depend on how long and severe the has lasted, which type it is and how well the person responds individually. Clinical treatment must be preceded by a physical exam.

A foul mood or slight gloominess is not depression. Depression, just like diabetes and high blood pressure, affects your daily thoughts, feelings and physical health. Health professionals can help treat a serious case of successfully.

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Another area warranting additional research is the potential that the association between and glycemic control is mediated through the deleterious impact of on self-care behaviors.

Postpartum or Post-Natal is clinical that occurs within two years of childbirth.

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